Prolong your energy, focus, and confidence with science-backed weight-loss therapy guided by medical experts.

Human vs Research Grade Peptides

ProlongMD prescribes only human grade peptides and only after medical evaluation, fulfilled by state licensed, FDA registered pharmacies, with professional oversight. Peptides sold online as research or animal grade products are not regulated for human use and may carry risks related to purity, dosing, and contamination.

Understanding the impact of metabolic dysfunction

Weight challenges are often driven by more than lifestyle alone. Stress, hormonal fluctuations, disrupted sleep, genetics, and environmental factors can all contribute to metabolic slowdown, appetite dysregulation, and insulin resistance—making weight loss increasingly difficult despite consistent effort. Without proper support, these issues can affect energy, confidence, and long-term health. Medical weight-loss therapies can help rebalance appetite signals, improve metabolic function, and make sustainable progress more achievable.

Warning signs to watch for

  • Stagnant or fluctuating weight despite consistent effort
  • Persistent hunger or cravings
  • Yo-yo dieting
  • Fatigue or low energy
  • Slowed metabolism
  • Early signs of insulin resistance
  • Family history of metabolic conditions

How it works

Your transformation is guided by data, precision, and board-certified medical expertise, every step of the way.

  • 01

    Start Your Care

    • Begin your clinician directed care journey
    • Book Medical Consultation, $79.
    • Check email for patient portal access.
    • Complete intake process in minutes.
  • 02

    Meet Virtually

    • Meet with a licensed medical provider via secure tele health video
    • Review symptoms, labs, and goals
    • Treatment and dosing are determined only if medically appropriate
    • Additional labs ordered if needed
  • 03

    Personalized Medical Oversight

    • Ongoing clinician-directed medical oversight
    • Prescriptions, when appropriate, filled by FDA-regulated pharmacies and shipped to your door

Our weight loss treatment options

Your clinician will recommend the most appropriate treatment and dosing based on your consultation.

SUPPORT

You have questions, we have answers.

Find answers to common questions about treatment options and our process. If you don't see your question here, our support team is ready to help.

Contact us

How does medical weight loss work?

Medical weight loss uses medications, clinical monitoring, and personalized support to address the biological factors that make weight loss challenging. These medications help regulate appetite, improve insulin sensitivity, reduce cravings, and support healthier metabolic function—making it easier to achieve and maintain weight loss.

Who qualifies for weight-loss medications?

Physicians evaluate your BMI, overall health, and conditions such as insulin resistance or high blood pressure to determine whether you are eligible for medication.

What’s the difference between semaglutide and tirzepatide?

Semaglutide is a GLP-1 medication that helps control hunger and stabilize blood sugar. Tirzepatide acts on both the GLP-1 and GIP pathways, providing stronger appetite control and often more rapid or greater weight loss. Both are effective; the best option depends on your goals, medical history, and your body's response.

Are these medications safe?

Yes—when prescribed by trained physicians and used as directed. Semaglutide and tirzepatide are prescription medications that have undergone extensive clinical trials showing strong safety profiles. Your provider monitors your dosing, progress, and any side effects to ensure treatment remains safe and effective for your individual health needs.

How soon will I start seeing results?

Many patients notice reduced hunger and cravings within 1–3 weeks. Visible weight loss typically begins within 3–8 weeks as your metabolism adjusts, with continued improvement when combined with healthy habits and support.

Do I need to follow a strict diet while on medication?

Strict dieting isn't required, but eating balanced meals, prioritizing protein, and staying hydrated can help you feel your best and optimize results. These medications naturally reduce appetite, making it easier to make healthier choices without feeling deprived or restricted.

Will I regain weight if I stop taking the medication?

Weight regain varies from person to person. Because these medications treat underlying metabolic issues, some people maintain their progress after stopping. However, lifestyle habits and continued support play a significant role. Your physician can help you transition off medication gradually and maintain your results long-term.

What side effects should I expect?

Common side effects, such as mild nausea or digestive changes, typically occur during dose escalation and often improve over time. These are monitored closely, and your physician will adjust your plan to minimize discomfort and ensure safety.

How long do I need to stay on treatment?

Treatment duration varies based on your goals and clinical needs. Many patients remain on medication until they reach a healthy, stable weight and feel confident maintaining it. Some continue treatment longer to support metabolic health or prevent regain. Your physician will guide you through each phase.

Can I use these medications if I have other health conditions?

In many cases, yes. People with insulin resistance, prediabetes, PCOS, or elevated blood sugar often benefit significantly from GLP-1 or GIP/GLP-1 therapies. Your physician will review your medical history, current medications, and lab work to ensure treatment is safe and appropriate for your situation.

Real People, Real Results

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"I just had my consult with Erica at ProlongMD and she truly knows her stuff. She was thorough, patient, and genuinely caring.We focused on sleep, hormones, and my fat loss goals. After reviewing my bloodwork, Erica identified important insights that had been missed by my previous providers.She recommended starting with targeted peptides and supplements through ProlongMD, with more advanced testing as a next step if needed. I am starting a nighttime peptide protocol and am excited to see my results."
Michelle T
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"My experience with Erica was superb! She quickly understood and assessed my needs. I felt heard. I recommend both ProlongMD and Erica particularly for anyone who is thinking through the inevitable implications of aging."
Sarah H
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"I was shocked at how much has gone unnoticed by my other medical providers over many years, things  I’ve been complaining about for a long time that were identified in my very first visit with the ProlongMD medical expert. I felt truly heard. Her thoroughness, clarity, and proactive approach left me excited and confident about embarking on my new healthcare plan. I finally feel like I have a provider who sees the whole picture and acts swiftly to optimize my health.   Highly recommend  ProlongMD for anyone seeking knowledgeable, attentive care in women’s health and weight loss."
Michelle G
Age 56
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"After surgical menopause in 2019, my weight climbed to 225 pounds despite working out 3–4 times a week and eating well. My A1C was approaching diabetic levels, and nothing seemed to work.Once I started a personalized medical approach that addressed hormone balance and insulin resistance, everything changed. I’ve lost 80 pounds and over 31 inches, dramatically reduced body fat, gained muscle, and brought my A1C back into a healthy range. My liver health has improved, autoimmune flare-ups are less frequent, and I feel stronger than ever.At 49, I’m in the best shape of my life—better than my 20s. My husband also joined the program for metabolic and hormone support and has seen excellent results."
Tiffany E
Age 49
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"At 57, ProlongMD has helped me restart my path toward optimal health. Despite staying active and eating well, I struggled for years with weight, A1c, and the feeling of slowing down. Diet and exercise alone weren’t enough.The ProlongMD team was responsive, thorough, and focused on the full picture of my health. After starting hormone therapy and peptide treatments—alongside continued training and nutrition—I noticed improved focus within days. A month in, my mental clarity, mood, and joint stiffness have all improved, and even my wife has noticed the difference. I’m feeling better physically and working out more consistently, and I’m excited to continue the process."
Rene T
Age 57
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"At 49 I thought my low energy was due to my high energy job and just getting older. I had terrible brain fog but thought it was because I was ADHD. I was also looking very fluffy and felt bloated so I upped  my training and focused alot on my nutrition. My weight wouldn’t budge. I decided to get some bloodwork done and found out I had no hormones and my thyroid was shot. I went on HRT and now I feel so much better and the weight started coming off. I knew hormones were important for weight loss but I didn’t realize how much. It’s not just calories in calories out. Now I’m committed to helping other women feel good as they age. "
Christy S
Age 54
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"Everything with ProlongMD was easy and efficient from the start. Scheduling was quick, the patient portal was simple to use, and uploading documents and completing forms only took a few minutes.The medical staff at ProlongMD were friendly, professional, and highly knowledgeable. The telehealth visit was far more in-depth than I expected—we covered topics my recent in-person visit didn’t, and the conversation felt unhurried and personal.Not having to drive across town saved me a significant amount of time. Overall, ProlongMD delivered convenient, high-quality care without the hassle. I highly recommend it for anyone who’s busy and looking for an affordable, thorough healthcare option."
Michell B
Age 42
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"Reaching out to ProlongMD was one of the best decisions I’ve made this year. After years of dealing with a serious health condition that left me chronically fatigued and mentally foggy, I finally found a path forward.The process was simple and efficient—I was able to upload existing labs and meet virtually with a knowledgeable, attentive provider who created a clear, personalized care plan. Pricing was transparent and competitive. Most importantly, the results have been real. Since starting treatment, my energy and mental clarity have noticeably improved, and for the first time in a long while, I feel like I’m moving in the right direction."
Todd H
Age 57
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“I have been having a great experience with Prolong MD! The doctor, Erica, has been extremely understanding and has taken the time to truly learn my health history and goals. She has been very thorough in reviewing my bloodwork and providing clear, thoughtful guidance on nutritional changes and supplements. The entire process has been simple, personalized, and genuinely helpful for improving my overall health.”
James S
Age 42